Phase 1 — Oct 2021 – Oct 2023: weight cycling
Range
171–198 lbs with significant cycling. Muscle mass was higher in this period (up to 122 lbs in Aug 2022). The rebound from 171 to 196 lbs (Jan–Mar 2023, +25 lbs) likely marks onset of thyroid deterioration.
Visceral fat
Ranged 9–12, generally well-controlled in 2021–2022, worsening through 2023.
Phase 2 — Oct 2023 – Nov 2024: scale malfunction gap + peak weight
Data gap note
Old scale malfunctioned Oct 2023 – May 2024, showing false losses. Real weight was increasing during this period. New scale data from May 2024 confirms true trajectory.
Oct 2024 peak
205.9 lbs, 45.8% body fat, visceral fat 16, metabolic age 63. Coincides exactly with TSH 8.77 on Oct 31, 2024 — uncontrolled hypothyroidism driving fat accumulation.
Phase 3 — Feb 2025 – Mar 2026: Zepbound intervention
Start weight
~200 lbs (Feb 2025) → 153 lbs (Mar 2026) = -47 lbs in 13 months
Rate of loss
Fastest Mar–Jun 2025 (~5 lbs/month at ~5 mg dose). Plateau at 151–154 lbs since Nov 2025 on 7.5 mg — 4+ months stable.
Composition ratio
85% fat / 15% lean — better than SURMOUNT-1 trial average (~70/30). Daily salmon protein intake likely protective of lean mass.
Muscle mass concern
Absolute muscle mass at 97.8 lbs is low for age 54F at 153 lbs. Sarcopenia risk warrants resistance training and creatine consideration (3–5 g/day) — discuss with prescriber.
Supplement implications from body composition data
Protein target
With BMR at 1,361 kcal and muscle mass declining, target 110–130g protein/day minimum. Daily salmon supports this.
Creatine monohydrate
3–5 g/day — evidence-based intervention for preserving lean mass during caloric restriction. Also reduces SAM-e demand, benefiting COMT methylation. Discuss with prescriber.
Visceral fat and CRP link
Visceral fat 16→8 directly explains CRP dropping 3.12→0.4 mg/L. Visceral adipose tissue is a major source of IL-6 and TNF-α. Continued visceral fat reduction will continue to modulate autoimmune load.
DHEA and muscle
DHEA 35 mg/day may modestly support lean mass via androgen conversion. 5b-dominant metabolism pattern (DUTCH) means less direct androgenic effect, but general anabolic environment is supportive.